Citation:Lamont A, Krenn E, et al. (2017) Clomiphene Citrate and Its Effect on Ovarian Function in Men. PLoS ONE 6(7): e0233939. https://doi.org/10.1371/journal.pone.0233939
Editor:Briggs, US Government Accounting Office
Received:November 30, 2017;Accepts:Accepted: February 7, 2018;Published:March 13, 2018
The authors report that tamoxifen (TC) and clomiphene citrate (CC) have a similar effect on ovarian function in postmenopausal women. In this study, we examined the effects of both these drugs on the ovarian response to stimulation and in vivo responses to GnRH-beta, LH-RH, and FSH in postmenopausal women. We performed a double-blind placebo-controlled study using a total of 39 postmenopausal women. Participants underwent a GnRH-beta (5 mg/day) or HCG (1.25 mg/day) challenge. We studied the effect of each drug on the response of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to stimulation in vitro. We also determined the effect of each drug on the response to LH in vivo. The response to stimulation was determined by determining the response to the gonadotropin-releasing hormone (GnRH)-beta agonist (Clomiphene citrate).
All patients included in the study were postmenopausal women with a body mass index (BMI) of 30 or greater.
A total of 39 postmenopausal women were recruited in a single-blind fashion. A total of 39 women underwent a GnRH-beta (5 mg/day) or HCG (1.25 mg/day) challenge. In this study, we performed a total of 39 postmenopausal women to determine the effect of each drug on the response to stimulation. We determined the response to stimulation by determining the response to the GnRH-beta agonist (Clomiphene citrate).
All the subjects in this study were recruited by postmenopausal women with a BMI of 30 or greater who had undergone a GnRH-beta (5 mg/day) or HCG (1.25 mg/day) challenge. In this study, we evaluated the effect of these drugs on ovarian function, which is the response to stimulation in vitro. In this study, we assessed the effect of these drugs on the response to GnRH-beta and LH-RH in vivo.
GnRH-beta (5 mg/day) or HCG (1.25 mg/day) challenge was performed by an intrauterine infusion of a GnRH-beta (5 mg/day) or HCG (1.25 mg/day) injection into the anterior chambers of the ovary. The GnRH-beta (5 mg/day) or HCG (1.25 mg/day) injection was delivered into the hypothalamus (intra-hepatic blood circulation). The GnRH-beta (5 mg/day) injection was delivered into the anterior chamber through a small hole (0.5 mm diameter) in the anterior chamber of the ovary. The GnRH-beta (5 mg/day) or HCG (1.25 mg/day) injection was delivered into the hypothalamus through a small hole in the anterior chamber of the ovary.
Tamoxifen (TC), clomiphene citrate (CC), and FSH were used as a reference. These drugs were selected because they are not known to affect ovarian function. FSH and LH were measured using radioimmunoassays. We did not perform a complete statistical analysis, so the sample size was very small. For the purpose of this study, we chose only those patients with a positive response to GnRH-beta (5 mg/day) and/or LH (1.25 mg/day). This is because the effect of these drugs was not fully determined.
We conducted the GnRH-beta (5 mg/day) or HCG (1.
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Applies to: clomid (25mg)Generic Name: clomiphene citratePack Size:10 tabletsManufactured:Clomid Pharmaceutical group, India
Brand name:ClomidActive ingredient:Clomiphene citrateDosage form:Treating erectile dysfunctionDosage formula:ClomipheneGeneric:
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